|Melting Point:||130-135°C||Alpha:||D24 +110° (c = 1 In Water Or Pyridine), +92° (c = 1 In DMF)|
|Boiling Point:||813.7±65.0 °C(Predicted)||Density:||1.69±0.1 G/cm3(Predicted)|
|Vapor Pressure:||Neglible At Room Temperature||Storage Temp.:||0-6°C|
|Water Solubility:||Readily Soluble||Pka:||6.0(at 25℃)|
37248-47-8 Medical Intermediates,
D-Chiro-Inositol Medical Intermediates
37248-47-8 White Powder D-Chiro-Inositol Medical Intermediates
Validamycin A is produced by the fermentation of Streptomyces hygroscopicus var. limoneus nov. var (30). Structure revised (31). Colorless, odorless, hygroscopic powder. V.p. Negligible at room temperature. Solubility: Readily soluble in water, soluble in methanol, dimethylformamide and dimethyl sulfoxide. Slightly soluble in ethanol and acetone. Sparingly soluble in diethyl ether and ethyl acetate. pKa 6.0 Stability [α]24D + 110? (water).
Validamycin A is the major analogue of a family of cyclitol disaccharides isolated from Streptomyces hygroscopicus var. limoneus by researchers at Takeda in 1970. Although commonly regarded as an aminoglycoside, validamycin shares little in common with conventional aminoglycosides such as streptomycin and gentamicin. Validamycin A is a potent antifungal agent and is used to control fungi in crop production. Validamycin A acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi.
Validamycin A specifically inhibits trehalase in R. solani AG-1 in a competitive manner between validoxylamine A (the possible active form of validamycin A) and the substrate, trehalose (33). Because trehalose is a storage carbohydrate in some fungi, trehalase is suggested to play an essential role for the digestion of trehalose to D-glucose and for its transportation to the hyphal tips (34).
Validamycin A is stable at room temperature in neutral or alkaline media but is unstable in acidic media.
Q1 Can i get some samples?
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
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Q4 What’s your MOQ?
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime?
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount?
A6 Different quantity has different discount.
Q7 How do you treat quality complaint?
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
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