| Place of Origin: | JIANGSU, CHINA |
|---|---|
| Brand Name: | Guanjia |
| Minimum Order Quantity: | Negotiable |
| Price: | Negotiable |
| Packaging Details: | 100g/foil bag; 1kg/foil bag |
| Payment Terms: | L/C,T/T, Western Union and Money Gram |
| Supply Ability: | 200 Kilogram/Kilograms per Month |
| Melting Point: | 130-135°C | Alpha: | D24 +110° (c = 1 In Water Or Pyridine), +92° (c = 1 In DMF) |
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| Boiling Point: | 813.7±65.0 °C(Predicted) | Density: | 1.69±0.1 G/cm3(Predicted) |
| Vapor Pressure: | Neglible At Room Temperature | Storage Temp.: | 0-6°C |
| Water Solubility: | Readily Soluble | Pka: | 6.0(at 25℃) |
| High Light: | 37248-47-8 Medical Intermediates,37248-47-8,D-Chiro-Inositol Medical Intermediates |
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37248-47-8 White Powder D-Chiro-Inositol Medical Intermediates
Description
Validamycin A is produced by the fermentation of Streptomyces hygroscopicus var. limoneus nov. var (30). Structure revised (31). Colorless, odorless, hygroscopic powder. V.p. Negligible at room temperature. Solubility: Readily soluble in water, soluble in methanol, dimethylformamide and dimethyl sulfoxide. Slightly soluble in ethanol and acetone. Sparingly soluble in diethyl ether and ethyl acetate. pKa 6.0 Stability [α]24D + 110? (water).
Uses
Validamycin A is the major analogue of a family of cyclitol disaccharides isolated from Streptomyces hygroscopicus var. limoneus by researchers at Takeda in 1970. Although commonly regarded as an aminoglycoside, validamycin shares little in common with conventional aminoglycosides such as streptomycin and gentamicin. Validamycin A is a potent antifungal agent and is used to control fungi in crop production. Validamycin A acts as a potent inhibitor of trehalase, an important enzyme in carbohydrate storage and ultilisation in fungi.
Pharmacology
Validamycin A specifically inhibits trehalase in R. solani AG-1 in a competitive manner between validoxylamine A (the possible active form of validamycin A) and the substrate, trehalose (33). Because trehalose is a storage carbohydrate in some fungi, trehalase is suggested to play an essential role for the digestion of trehalose to D-glucose and for its transportation to the hyphal tips (34).
Degradation
Validamycin A is stable at room temperature in neutral or alkaline media but is unstable in acidic media.
Q1 Can i get some samples?
A1 Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2 How to start orders or make payments?
A2 Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q3 How to confirm the Product Quality before placing orders?
A3 You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4 What’s your MOQ?
A4 Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5 How about delivery leadtime?
A5 Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6 Is there a discount?
A6 Different quantity has different discount.
Q7 How do you treat quality complaint?
A7 First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8 How to contact us ?
A9 You can choose your interested products and send inquiry to us.
